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Esophageal Ulceration Induced by Zidovudine

Paul Edwards, MB; Jennifer Turner, MB; Julian Gold, MB; and David A. Cooper, MD
[+] Article and Author Information

Grant Support: By the NSW Department of Health and a Commonwealth Department of Health AIDS Research Grant.

Requests for Reprints: David A. Cooper, Director, NHMRC Special Unit in AIDS Epidemiology and Clinical Research, 150 Albion Street, Sydney, NSW 2010, Australia.

Current Author Addresses: Mr. Edwards: Bruce Hall Department of Gastroenterology, St. Vincent's Hospital, Sydney, NSW 2010, Australia.

Ms. Turner: Department of Anatomical Pathology, St. Vincent's Hospital, Sydney, NSW 2010, Australia.

Mr. Gold: Albion Street Centre, 150 Albion Street, Sydney, NSW 2010, Australia.

Dr. Cooper: NHMRC Special Unit in AIDS Epidemiology and Clinical Research, 150 Albion Street, Sydney, NSW 2010, Australia.


Ann Intern Med. 1990;112(1):65-66. doi:10.7326/0003-4819-112-1-65
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This excerpt has been provided in the absence of an abstract.

Esophageal injury induced by oral medication is well documented by over 300 case reports (1-3). In two major studies (1, 2), age, posture, volume of fluid chaser, and dissolution pH of the medication were identified as the major factors influencing esophageal injury. Zidovudine, an antiviral agent capable of inhibiting in-vitro replication of the human immunodeficiency virus (HIV), is the only treatment of proven efficacy for persons with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. Because of zidovudine's pharmacokinetic profile, it is recommended that it be taken every 4 hours around the clock to obtain maximum virustatic effect.

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