The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Reports |

Esophageal Ulceration Induced by Zidovudine

Paul Edwards, MB; Jennifer Turner, MB; Julian Gold, MB; and David A. Cooper, MD
[+] Article and Author Information

Grant Support: By the NSW Department of Health and a Commonwealth Department of Health AIDS Research Grant.

Requests for Reprints: David A. Cooper, Director, NHMRC Special Unit in AIDS Epidemiology and Clinical Research, 150 Albion Street, Sydney, NSW 2010, Australia.

Current Author Addresses: Mr. Edwards: Bruce Hall Department of Gastroenterology, St. Vincent's Hospital, Sydney, NSW 2010, Australia.

Ms. Turner: Department of Anatomical Pathology, St. Vincent's Hospital, Sydney, NSW 2010, Australia.

Mr. Gold: Albion Street Centre, 150 Albion Street, Sydney, NSW 2010, Australia.

Dr. Cooper: NHMRC Special Unit in AIDS Epidemiology and Clinical Research, 150 Albion Street, Sydney, NSW 2010, Australia.

Ann Intern Med. 1990;112(1):65-66. doi:10.7326/0003-4819-112-1-65
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Esophageal injury induced by oral medication is well documented by over 300 case reports (1-3). In two major studies (1, 2), age, posture, volume of fluid chaser, and dissolution pH of the medication were identified as the major factors influencing esophageal injury. Zidovudine, an antiviral agent capable of inhibiting in-vitro replication of the human immunodeficiency virus (HIV), is the only treatment of proven efficacy for persons with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. Because of zidovudine's pharmacokinetic profile, it is recommended that it be taken every 4 hours around the clock to obtain maximum virustatic effect.

We report


First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.