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Hypophosphatemia Complicating Management of Acute Severe Asthma

Jean-Pierre Laaban, MD; Myrna Waked, MD; Muriel Laromiguiere, PharmD; Tu-Khanh Vuong, MD; and Jacques Rochemaure, MD
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Requests for Reprints: Jean-Pierre Laaban, MD, Department of Pneumology and Intensive Care, Hôtel-Dieu de Paris, 1 place du Parvis Notre-Dame, F-75181, Paris Cédex 04, France.

Current Author Addresses: Drs. Laaban, Waked, Vuong, and Rochemaure: Department of Pneumology and Intensive Care, Hôtel-Dieu de Paris, 1 place du Parvis Notre-Dame, F-75181, Paris Cédex 04, France. Dr. Laromiguiere: Department of Biochemistry and Toxicology, Hôtel-Dieu de Paris, 1 place du Parvis Notre-Dame, F-75181, Paris Cédex 04, France.

Ann Intern Med. 1990;112(1):68-69. doi:10.7326/0003-4819-112-1-68
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This excerpt has been provided in the absence of an abstract.

The correction of acute respiratory acidosis by mechanical ventilation in patients with chronic obstructive pulmonary disease has been shown to induce hypophosphatemia (1-3). In patients with acute respiratory failure, hypophosphatemia may have harmful effects because it may decrease diaphragmatic contractility (4) and impair tissue oxygenation by causing a decrease in the erythrocyte 2,3-diphosphoglycerate concentration (5). However, the variations in serum phosphorus levels have not been studied in other settings of acute respiratory acidosis. We aimed to determine whether hypophosphatemia may develop during the treatment of acute severe asthma.

Patients and Methods: We did a prospective study of 18 consecutive patients


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