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Octreotide Is Effective in Acromegaly But Often Results in Cholelithiasis

William H. Daughaday, MD
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Washington University School of Medicine
St. Louis, Missouri

Ann Intern Med. 1990;112(3):159-160. doi:10.7326/0003-4819-112-3-159
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In this issue, Ho and colleagues (1) summarize their considerable experience in treating acromegaly with the long-acting somatostatin analog, octreotide. This agent has a much longer biologic half-life than somatostatin and its effects persist from 4 to 8 hours. Ho and colleagues found that when octreotide was administered twice a day, little additional benefit was gained by increasing each dose from 100 to 500 μg. Serum growth hormone (GH) was lowered more successfully with three doses a day but little benefit was added by increasing the amount of each dose from 100 to 500 μg. Some patients are resistant to


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