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Rhabdomyolysis and Acute Renal Failure Induced by Combination Lovastatin and Gemfibrozil Therapy

Gary E. Marais, MB, ChB; and Kerry K. Larson, MD
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Requests for Reprints: Gary E. Marais, MB, ChB, Cardiology Section, Department of Internal Medicine, Jerry L. Pettis Memorial Veterans Hospital, 11201 Benton Street, Loma Linda, CA 92357.

Current Author Addresses: Dr. Marais: Cardiology Section, Department of Internal Medicine, Jerry L. Pettis Memorial Veterans Hospital, 11201 Benton Street, Loma Linda, CA 92357.

Dr. Larson: Department of Internal Medicine (SGHMI), 354th Medical Group (TAC), Myrtle Beach Air Force Base, SC 29579.

Ann Intern Med. 1990;112(3):228-230. doi:10.7326/0003-4819-112-3-228
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This excerpt has been provided in the absence of an abstract.

Lovastatin is a new lipid-lowering drug that has shown great promise in the treatment of patients with hypercholesterolemia (1, 2). It is the first available agent in a new class of drugs that inhibit the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase, which catalyzes the rate-limiting step in cholesterol synthesis (3). Lovastatin is well tolerated and few severe adverse effects have been reported (4). Myopathy, defined as muscle pain or weakness associated with markedly elevated creatine kinase levels, has a reported incidence of 0.5% (4). Rhabdomyolysis has been reported in 30% of patients when the drug is used concomitantly with immunosuppressive drugs


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