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Risk for Non-A, Non-B (Type C) Hepatitis through Sexual or Household Contact with Chronic Carriers

James E. Everhart, MD; Adrian M. Di Bisceglie, MD; Linda M. Murray, RN; Harvey J. Alter, MD; Jacqueline J. Melpolder, MT; George Kuo, PhD; and Jay H. Hoofnagle, MD
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Requests for Reprints: James Everhart, MD, Room 106, Federal Building, 7550 Wisconsin Avenue, Bethesda, MD 20892.

Current Author Addresses: Dr. Everhart: Room 106, Federal Building 7550 Wisconsin Avenue, Bethesda, MD 20892.

Drs. Di Bisceglie and Hoofnagle and Ms. Murray: Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.

Dr. Alter and Ms. Melpolder: Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892.

Dr. Kuo: The Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608.

Ann Intern Med. 1990;112(7):544-545. doi:10.7326/0003-4819-112-7-544
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This excerpt has been provided in the absence of an abstract.

Transmission of non-A, non-B hepatitis through parenteral exposures, including drug abuse, blood transfusion, and occupational injury with a needle contaminated with blood is well documented (1). Other means of non-A, non-B hepatitis transmission must occur, since at least 50% of patients do not have a history of parenteral exposure (2, 3). Personal contact as a route of infection has been reported (4), but not shown conclusively, and the actual risk for such transmission is unknown.

Recently, the genome of the hepatitis C virus (HCV), the major agent that causes non-A, non-B hepatitis, has been isolated (5). Antibody to hepatitis C




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