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The Fat Overload Syndrome: Successful Treatment with Plasma Exchange

Marin H. Kollef, MD; Michael T. McCormack, MD; William E. Caras, MD; Vishnu V.B. Reddy, MD; and David Bacon, MD
[+] Article, Author, and Disclosure Information

Requests for Reprints: Marin H. Kollef, MAJ, MC, USA, Director, Medical Intensive Care Unit, Fitzsimons Army Medical Center, Aurora, CO 80045-5001.

Current Author Addresses: Drs. Kollef and McCormack: Pulmonary Disease Clinic, Fitzsimons Army Medical Center, Aurora, CO 80045-5001.

Dr. Caras: Pulmonary Disease Clinic, Tripler Army Medical Center, Honolulu, HI 96859.

Dr. Reddy: Department of Pathology, Fitzsimons Army Medical Center, Aurora, CO 80045-5001.

Dr. Bacon: Department of Pathology, U.S. Army Hospital, Nurnberg, West Germany.

Ann Intern Med. 1990;112(7):545-546. doi:10.7326/0003-4819-112-7-545
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This excerpt has been provided in the absence of an abstract.

The fat overload syndrome is a rare complication of the intravenous administration of fat emulsion. It is characterized by sudden elevation of the serum triglyceride level associated with fever, hepatosplenomegaly, coagulopathy, and variable end-organ dysfunction (1-3). Specific successful therapy other than supportive care for the fat overload syndrome has not been described. We report the first successful use of plasma exchange in treating this condition.

Case Report: A 39-year-old man was admitted to a community hospital for an exacerbation of his long-standing asthma. He was treated with intravenous theophylline, erythromycin, and nebulized metaproterenol. On the second hospital day, supplemental parenteral


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