0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Serial Impedance Plethysmography in Pregnant Patients with Clinically Suspected Deep-Vein Thrombosis: Clinical Validity of Negative Findings

Russell D. Hull, MBBS, MSC; Gary E. Raskob, MSC; and Cedric J. Carter, MBBS
[+] Article and Author Information

Grant Support: Supported by grants from the Ontario Ministry of Health, the Heart and Stroke Foundation of Ontario, and the Canadian Heart Foundation.

Requests for Reprints: Russell D. Hull, MBBS, MSc, The University of Calgary, Department of Medicine, Foothills Hospital, 3330 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada.

Current Author Addresses: Dr. Hull and Mr. Raskob: The University of Calgary, Department of Medicine, Foothills Hospital, 3330 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada. Dr. Carter: Department of Pathology, University Hospital—UBC Site, 2211 Wesbrook Mall, Vancouver, British Columbia V6T 2B5, Canada.


© 1990 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1990;112(9):663-667. doi:10.7326/0003-4819-112-9-663
Text Size: A A A

Study Objective: To determine the safety of withholding anticoagulant therapy in pregnant patients with clinically suspected deep-vein thrombosis who have negative results by serial impedance plethysmography.

Design: Prospective study evaluating prognosis by long-term follow-up to 3 months postpartum in all patients.

Setting: University-affiliated community hospital and referral center.

Patients: One hundred fifty-two consecutive pregnant patients referred with clinically suspected deep-vein thrombosis. All patients completed the study.

Interventions: Anticoagulant therapy was withheld in 139 patients negative by serial impedance plethysmography, and the patients were followed long term.

Measurements and Main Results: None of 139 patients (0%; 95% CI, 0% to 2.6%) had symptomatic pulmonary embolism or recurrent venous thrombosis.

Conclusions: The findings establish the safety of withholding anticoagulant therapy in pregnant patients who have negative results after serial impedance plethysmography. Sufficient patients were entered to provide narrow confidence intervals on the outcomes observed in patients with negative findings by impedance plethysmography. These findings are similar to those seen after venography in symptomatic patients. These data extend the role of non-invasive testing in patients with clinically suspected deep-vein thrombosis to the pregnant symptomatic patient.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)