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Treatment of Hypercholesterolemia in the Elderly

Stephanie D. Kafonek, MD; and Peter O. Kwiterovich, MD
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Requests for Reprints: Stephanie D. Kafonek, MD, Johns Hopkins University Lipid Clinic, 600 North Wolfe Street, CMSC 604, Baltimore, MD 21205.

Johns Hopkins University Lipid Clinic
Baltimore, MD 21205

Ann Intern Med. 1990;112(10):723-725. doi:10.7326/0003-4819-112-10-723
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This excerpt has been provided in the absence of an abstract.

The major cause of death in elderly persons is atherosclerotic cardiovascular disease (1). This is not a phenomenon of normal human aging, but rather, a disease manifestation of extended cumulative exposure to conventional and unconventional risk factors. Most of the risk factors that predict coronary heart disease (CHD) in middle-aged persons also predict CHD in older persons (2).

The causal relationship between elevated total plasma cholesterol concentrations and CHD has been well established in middle-aged persons (3, 4). Analyses of data from prospective population studies have shown that this relationship also holds for persons aged 60 years and older (5-10).


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