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Molecular Genetic Advances in Chronic Myelogenous Leukemia

Daniel E. Epner, MD; and H. Phillip Koeffler, MD
[+] Article and Author Information

Grant support: By National Institutes of Health grant GM 08243, USPHS grants CA26038, CA32737, CA33936, and the Leukemia Fund in memory of Marilyn Levine and Erwin Epstein.

Requests for Reprints: Daniel E. Epner, MD, Laboratory of Biomedical and Environmental Sciences, 900 Veteran Avenue, Los Angeles, CA 90024-1786.


Ann Intern Med. 1990;113(1):3-6. doi:10.7326/0003-4819-113-1-3
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While cytogenetics has been central to the study of chronic myelogenous leukemia since the discovery of the Philadelphia chromosome (Ph1) in 1960 (1, 2), the major thrust of research in recent years has been the clarification of the pathogenesis of the disease at the molecular level. Of the many variants of the Ph1 which are known to exist, all share one crucial molecular event. Abelson proto-oncogene, or ABL, is translocated from the long arm of chromosome 9 to a position adjacent to the breakpoint cluster region (BCR) gene on chromosome 22 (Figure 1, top).

The ABL gene is the normal

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