The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Molecular Genetic Advances in Chronic Myelogenous Leukemia

Daniel E. Epner, MD; and H. Phillip Koeffler, MD
[+] Article, Author, and Disclosure Information

Grant support: By National Institutes of Health grant GM 08243, USPHS grants CA26038, CA32737, CA33936, and the Leukemia Fund in memory of Marilyn Levine and Erwin Epstein.

Requests for Reprints: Daniel E. Epner, MD, Laboratory of Biomedical and Environmental Sciences, 900 Veteran Avenue, Los Angeles, CA 90024-1786.

Ann Intern Med. 1990;113(1):3-6. doi:10.7326/0003-4819-113-1-3
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

While cytogenetics has been central to the study of chronic myelogenous leukemia since the discovery of the Philadelphia chromosome (Ph1) in 1960 (1, 2), the major thrust of research in recent years has been the clarification of the pathogenesis of the disease at the molecular level. Of the many variants of the Ph1 which are known to exist, all share one crucial molecular event. Abelson proto-oncogene, or ABL, is translocated from the long arm of chromosome 9 to a position adjacent to the breakpoint cluster region (BCR) gene on chromosome 22 (Figure 1, top).

The ABL gene is the normal


First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.