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Editorials |

Fluconazole, a New Antifungal Agent

John N. Galgiani, MD
[+] Article and Author Information

Grant Support: In part by the Department of Veterans Affairs and the NIAID Mycoses Study Group, contract NO1-AI-5256.


Veterans Affairs Medical Center
College of Medicine, University of Arizona
Tucson, AZ 85723


Ann Intern Med. 1990;113(3):177-179. doi:10.7326/0003-4819-113-3-177
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In January, fluconazole was licensed by the Food and Drug Administration (FDA) for use in treating cryptococcosis and candidal infections in the United States. Interest in this compound among investigators has been much broader because fluconazole has shown activity in experimental animal infections that include coccidioidomycosis, histoplasmosis, blastomycosis, and aspergillosis. This azole congener is the most recent of several to be licensed for the treatment of systemic fungal infections. The first, miconazole, has not been widely used. This agent typically requires several daily parenteral doses and produces its own set of toxicities. Ketoconazole was the next azole antifungal to be

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