0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Multicentric Angiofollicular Lymph Node Hyperplasia with Peripheral Neuropathy, Pseudotumor Cerebri, IgA Dysproteinemia, and Thrombocytosis in Women: A Distinct Syndrome

John M. Feigert, MD; Donald L. Sweet, MD; Morton Coleman, MD; Diana Variakojis, MD; Nathaniel Wisch, MD; Julius Schulman, MD; and Martin H. Markowitz, MD
[+] Article and Author Information

Requests for Reprints: Morton Coleman, MD, 407 East 70th Street, New York, NY 10021.

Current Author Addresses: Dr. Feigert: New Hampshire Oncology-Hematology, PA, 200 Technology Drive, Hooksett, NH 03106.

Dr. Sweet: 333 Chestnut Street, Suite LL3, Hinsdale, IL 60521.

Dr. Coleman: 407 E. 70th Street, New York, NY 10021.

Dr. Variakojis: Department of Pathology, Northwestern University Medical College, Ward Memorial Building, 303 E. Chicago Avenue, Chicago, IL 60611.

Drs. Wisch and Schulman: 12 East 86th Street, New York, NY 10028.

Dr. Markowitz: 250 East 73rd Street, New York, NY 10021.


©1990 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1990;113(5):362-367. doi:10.7326/0003-4819-113-5-362
Text Size: A A A

Four women with multicentric angiofollicular lymph node hyperplasia had a distinct clinical syndrome characterized by peripheral neuropathy, pseudotumor cerebri, IgA dysproteinemia, and thrombocytosis. The nodes displayed typical morphologic changes of the plasma cell variant of multicentric angiofollicular lymph node hyperplasia. The pathologic changes are morphologically distinct from angioimmunoblastic lymphadenopathy with dysproteinemia although clinical similarities do exist. In these four cases, the lymphadenopathy was usually bulky and multicentric. There was frequent splenic involvement. The neuropathies were severe and disabling. Clinical courses have been variable with some responses to therapy with steroids and alkylating agents. No neoplastic transformations have occurred. Multicentric angiofollicular lymph node hyperplasia may represent a reactive lesion in which the antigenic stimulus is unknown but results in follicular hyperplasia, angiogenesis, and the systemic manifestations of hyperimmune stimulation. We believe this clinical syndrome may represent a distinct variant of multicentric angiofollicular lymph node hyperplasia, and it requires close observation for neoplastic transformation and other complications of its multisystem nature.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)