The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Is Hepatitis C Virus Involved in Hepatitis-Associated Aplastic Anemia?

Pol Stanislas, MD; Françoise Driss, MD; Agnès Devergie, MD; Christian Brechot, MD, PhD; Pierre Berthelot, MD; and Eliane Gluckman, MD
[+] Article, Author, and Disclosure Information

Grant Support: Dr. Pol was supported by the Fonds d'Etudes et de Recherche du Corps Médical des Hôpitaux de Paris.

Requests for Reprints: Stanislas Pol, MD, Unité d'Hépatologie, Hôpital Laënnec, 42 Rue de Sèvres, 75340 Paris Cedex 07, France.

Current Author Addresses: Drs. Pol, Driss, Bréchot, and Berthelot: Unité d'Hépatologie, Hôpital Laënnec, 42 rue de Sèvres, 75340 Paris Cedex 07, France.

Drs. Devergie and Gluckman: Unité de Greffe de Moëlle, Hôpital Saint-Louis, 2 place du Dr. Alfred Fournier, 75010 Paris, France.

© 1990 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1990;113(6):435-437. doi:10.7326/0003-4819-113-6-435
Text Size: A A A

Objective: To determine whether hepatitis C virus is involved in hepatitis-associated aplastic anemia.

Design: Retrospective analysis.

Setting: Bone marrow transplantation unit.

Patients: One hundred and eighteen patients with severe aplastic anemia, including 19 with hepatitis-associated aplasia, 61 with aplastic anemia of undetermined cause, and 38 with aplastic anemia related to an inherited syndrome or an acquired etiology.

Measurements and Main Results: There was no statistically significant difference in antihepatitis C virus antibodies between hepatitis-related aplastic anemia (15.8%; 95% CI, 4% to 36%) and aplasia of unknown (9.8%; CI, 5% to 22%) or known (7.9%; CI, 2% to 22%) cause. The antihepatitis C virus levels did not differ according to the cause of aplastic anemia. There was no relation between hepatitis C and hepatitis B virus serologies, regardless of cause.

Conclusions: Hepatitis C virus is not a frequent cause of non-A, non-B hepatitis-associated aplastic anemia. Either a non-A, non-B, non-C hepatitis virus is involved in non-A, non-B hepatitis-related aplasia or hepatitis C virus prevalence is underestimated in patients with hepatitis-related aplasia, possibly as a result of immunologic defects.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.