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The Systemic Capillary Leak Syndrome: Appearance of Interleukin-2-Receptor-Positive Cells during Attacks

Marco Cicardi, MD; Marco Gardinali, MD; Giuliana Bisiani, MD; Alberto Rosti, MD; Paola Allavena, MD; and Angelo Agostoni, MD
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Requests for Reprints: Angelo Agostoni, MD, Clinica Medica, Universitàdi Milano, Ospedale S. Paolo, Via di Rudinì 8, 20142 Milano, Italy.

Current Author Addresses: Drs. Cicardi, Gardinali, Bisiani, Rosti, and Agostoni: Clinica Medica Università di Milano, Ospedale S. Paolo, Via di Rudinì 8, 20142 Milano, Italy.

Dr. Allavena: Istituto di Ricerche Farmacologiche Mario Negri, Viale Eritrea 62, 20100 Milano, Italy.

Ann Intern Med. 1990;113(6):475-477. doi:10.7326/0003-4819-113-6-475
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Recurrent hypovolemic shock due to leakage of plasma from the vascular space without an apparent cause was first described by Clarkson and colleagues (1) in 1960 and was subsequently characterized as systemic capillary leak syndrome (2). Since then, 18 patients have been described, most of whom had an M component in their plasma (3). However, the pathogenesis of this syndrome remains unknown. A clue may come from the fact that the syndrome is also a major complication of treatment of metastatic cancer with interleukin-2 alone or in combination with lymphokine-activated killer cells (4). Studies in animals and in humans showed


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