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Myopathy with Human Immunodeficiency Virus Type 1 (HIV-1) Infection: HIV-1 or Zidovudine?

Michele Till, MD; and Keith B. MacDonell, MD
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Requests for Reprints: Michele Till, MD, Section of Infectious Diseases, Northwestern University Medical School, Passavant Pavilion, Room 828, 303 East Superior Street, Chicago, IL 60611.

Northwestern University Medical School
Chicago, IL 60611

Ann Intern Med. 1990;113(7):492-494. doi:10.7326/0003-4819-113-7-492
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Recent data indicate that early therapy with zidovudine is beneficial in slowing disease progression in persons infected with the human immunodeficiency virus type 1 (HIV-1) when CD4 cell counts are less than 500 cells/ mm3 (1). Many persons infected with HIV-1 will be taking zidovudine over long periods, and clinicians may be faced with related complications. One such complication is the development of a drug-induced myopathy. Although muscle pathologies including inflammatory myopathy (2-5), type II atrophy (6), and nemaline rod myopathy (2, 7, 8) had been described in association with HIV-1 infection before use of zidovudine, there are now several


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