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Transfusion of Blood Components from a Donor with Human T-Lymphotropic Virus Type II (HTLV-II) Infection

Elizabeth Donegan, MD; Michael P. Busch, MD, PhD; Janice A. Galleshaw, MD; George M. Shaw, MD, PhD; James W. Mosley, MD, Transfusion Safety Study Group*
[+] Article and Author Information

The following are members of the Protocol and Data Monitoring Committee: H. J. Alter, D. J. A'Allessio, G. J. Grady, P. V. Holland, N. R. Rose, L. B. Seeff, J. Wittes.

Grant Support: By contract N01-HB-4-7002, N01-HB-4-7003, and N01-HB-9-7074 from the National Heart, Lung, and Blood Institute.

Requests for Reprints: James W. Mosley, MD, University of Southern California, 1840 North Soto Street (EDM 108), Los Angeles, CA 90032.

Current Author Addresses: Dr. Donegan: University of California, San Francisco, Department of Laboratory Medicine, P.O. Box 0100, San Francisco, CA 94143.

Dr. Busch: Irwin Memorial Blood Bank, 270 Masonic Avenue, San Francisco, CA 94118-9990.

Drs. Galleshaw and Shaw: University of Alabama at Birmingham, 1900 University Boulevard, THT 513, Birmingham, AL 35294. Dr. Mosley: University of Southern California, 1840 North Soto Street (EDM 108), Los Angeles, CA 90032.


From the University of California, San Francisco, and Irwin Memorial Blood Center, San Francisco, California; the University of Alabama at Birmingham, Birmingham, Alabama; and the University of Southern California, Los Angeles, California.*Members of the Transfusion Safety Study Group are listed in the Acknowledgments section at the end of text.


Ann Intern Med. 1990;113(7):555-556. doi:10.7326/0003-4819-113-7-555
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This excerpt has been provided in the absence of an abstract.

Human T-lymphotropic virus type I (HTLV-I) is an etiologic agent of adult T-cell leukemia and of spastic myelopathy. Type II virus (HTLV-II) has been recovered from three patients with hairy cell leukemia and from one with exfoliative erythroderma (1-3), but the lack of evidence that HTLV-II infection is associated with other diseases is not necessarily meaningful because generally available serologic tests do not distinguish between HTLV-I and HTLV-II (4). The knowledge that HTLV-I can be transmitted by transfusion (5) prompted routine blood-donor screening in the United States and notification of past recipients of blood from positive donors (6, 7).

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