0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Reviews |

The Soluble Interleukin-2 Receptor: Biology, Function, and Clinical Application

Laurence A. Rubin, MD; and David L. Nelson, MD
[+] Article and Author Information

Drs. Rubin, Nelson and colleagues are named as inventors on a patent for the measurement of soluble interleukin-2 receptors, which has been assigned to the Government of the United States of America. Drs. Rubin and Nelson have no financial, consultative or other specific relations with those companies that produce and market the soluble IL-2R ELISA under license from the U.S. government.

Grant Support: In part by the Arthritis Society of Canada, the Heart and Stroke Foundation, and the Medical Research Council of Canada.

Requests for Reprints: Laurence A. Rubin, MD, University of Toronto, Medical Sciences Building, Room 5242, Toronto, Ontario M5S 1A8.

Current Author Addresses: Dr. Rubin: University of Toronto, Medical Sciences Building, Room 5242, Toronto, Ontario M5S 1A8. Dr. Nelson: Building 10, Room 4N115, National Institutes of Health, Bethesda, MD 20892.


© 1990 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1990;113(8):619-627. doi:10.7326/0003-4819-113-8-619
Text Size: A A A

Purpose: To review the biologic origin, functional characteristics, and current and potential clinical applications of a novel marker of immune system activation, the soluble interleukin-2 receptor (SIL-2R).

Data Identification: Studies reported since 1985 were identified by a computer search using MEDLINE as well as from bibliographies of published work.

Study Selection: Sixty-two reports on the clinical applications of the sIL-2R, largely from peer-reviewed journals, were identified. These reports address the utility and significance of sIL-2R measurements in various conditions. Basic scientific investigations delineating the biochemical and molecular features of the human interleukin-2 receptor complex and the sIL-2R protein were reviewed.

Data Extraction: The validity of sIL-2R quantitation as an index of in-vivo immune system activation and its usefulness as a measure of disease activity and outcome were examined.

Results of Data Analysis: The quantitation of sIL-2R, a novel laboratory measure of in-vivo immune system activation, correlates reliably with disease activity in autoimmune inflammatory disorders, transplantation rejection, and specific infectious disorders. Markedly elevated serum sIL-2R levels are a particularly prominent feature of certain hematologic malignancies, such as human T lymphotropic retrovirus type I-associated adult T-cell leukemia and hairy cell leukemia, reflecting tumor burden and response to therapy. The sIL-2R level at disease onset may also reliably predict long-term prognosis in non-Hodgkin lymphoma, and it appears to provide an additional serologic measure in the assessment of clinical progression in patients with human immunodeficiency virus infection and the acquired immunodeficiency syndrome.

Conclusions: Studies have suggested that sIL-2R levels offer a rapid, reliable, and noninvasive measure of disease activity, response to therapy, and, in some cases, prognosis in a broad spectrum of conditions associated with T- or B-cell immune activation.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)