0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Treatment of Postmenopausal Osteoporosis with High Doses of Synthetic Calcitriol: A Randomized Controlled Study

J. C. Gallagher, MD; and D. Goldgar, PhD
[+] Article and Author Information

Grant Support: By a grant from Hoffman La Roche, Nutley, New Jersey.

Requests for Reprints: J.C. Gallagher, MD, Bone Metabolism Unit, Creighton University Medical Center, 601 North 30th Street, Suite 5730, Omaha, NE 68131.

Current Author Addresses: Dr. Gallagher: Creighton University Medical Center, 601 North 30th Street, Suite 5730, Omaha, NE 68131.

Dr. Goldgar: Department of Medical Informatics, University of Utah, Salt Lake City, UT 48108.


© 1990 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1990;113(9):649-655. doi:10.7326/0003-4819-113-9-649
Text Size: A A A

Objective: To study the efficacy of synthetic 1,25 dihydroxyvitamin D3 (calcitriol) in the treatment of osteoporosis.

Design: Two-year, double-blind, randomized clinical trial.

Setting: University medical center.

Patients: Fifty postmenopausal women with vertebral fractures recruited by referral.

Intervention: Calcium intake was adjusted to 25 mmol/d (1000 mg/d) at baseline. Patients were then randomized to treatment with either calcitriol or placebo. During the study, calcium intake was reduced to 15 mmol/d (600 mg/d) and the dose of calcitriol was adjusted to maintain serum calcium < 2.74 mmol/L (< 11.0 mg/dL) or urine calcium < 9.96 mmol/d (< 400 mg/d).

Measurements and Main Results: After 2 years, the mean dose of calcitriol in the treated group was 0.62 µg/d. Bone mineral density of the spine increased 1.94% with calcitriol therapy and decreased 3.92% with placebo (P = 0.001). Total body calcium increased 0.21% with calcitriol therapy and decreased 1.85% with placebo (P = 0.004). Patients receiving placebo had significant decreases in spine density (P = 0.0007) and total body calcium (P = 0.0004). There were no differences in vertebral fracture rates between the groups. Renal function studies were not statistically different between the groups after 2 years.

Conclusion: The treatment of postmenopausal osteoporotic women with synthetic calcitriol for 2 years was associated with increases in spine density and total body calcium. No adverse effects on renal function were seen after long-term calcitriol therapy.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)