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Corticosteroid-Associated Blue Toe Syndrome: Role of Antiphospholipid Antibodies

Gregg E. Davies, MD; and Douglas A. Triplett, MD
[+] Article and Author Information

Requests for Reprints: Gregg E. Davies, MD, Medical Service (111K), Veterans Affairs Medical Center, 1900 East Main Street, Danville, IL 61832.

Current Author Addresses: Dr. Davies: Medical Service (111K), Veterans Affairs Medical Center, 1900 East Main Street, Danville, IL 61832. Dr. Triplett: Department of Pathology, Ball Memorial Hospital, 2401 University Avenue, Muncie, IN 47303.


Ann Intern Med. 1990;113(11):893-895. doi:10.7326/0003-4819-113-11-893
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Antiphospholipid antibodies may be found in patients with various diseases, especially in those with systemic lupus erythematosus, or in patients without any apparent predisposing condition. The presence of antiphospholipid antibodies in patients with systemic lupus erythematosus is significantly associated with venous or arterial thromboembolism, neurologic disorders, and thrombocytopenia (1). In patients without systemic lupus erythematosus, an association between antiphospholipid antibodies and thromboembolic or other disorders has been strongly suspected but not conclusively proved (2, 3). We describe a patient with antiphospholipid antibodies and thrombocytopenia who twice developed the blue toe syndrome after receiving treatment with prednisone to increase the platelet

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