0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

High Blood Cholesterol in Elderly Men and the Excess Risk for Coronary Heart Disease

Susan M. Rubin, MPH; Stephen Sidney, MD, MPH; Dennis M. Black, PhD; Warren S. Browner, MD, MPH; Stephen B. Hulley, MD, MPH; and Steven R. Cummings, MD
[+] Article and Author Information

Grant Support: In part by the Henry J. Kaiser Family Foundation Faculty Fellowship in General Internal Medicine and by the Kaiser Foundation Research Institute.

Requests for Reprints: Susan M. Rubin, MPH, University of California at San Francisco, Prevention Sciences Group, Box 0886, San Francisco, CA 94143.

Current Author Addresses: Ms. Rubin and Drs. Black, Browner, Hulley, and Cummings: University of California at San Francisco, Prevention Sciences Group, Box 0886, San Francisco, CA 94143.

Dr. Sidney: Division of Research, Kaiser Permanente Medical Care Program, 3451 Piedmont Avenue, Oakland, CA 94611.


© 1990 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1990;113(12):916-920. doi:10.7326/0003-4819-113-12-916
Text Size: A A A

Objective: To determine whether high blood cholesterol is an important risk factor for mortality from coronary heart disease in elderly men.

Design: Cohort study with a mean follow-up of 10.1 years.

Setting: A health maintenance organization.

Patients: The cohort included 2746 white men 60 to 79 years of age who had no self-reported history of coronary heart disease.

Measurement and Main Results: A total of 260 deaths occurred during 27 842 person-years of follow-up. The relative risk for mortality from coronary heart disease in men 60 to 79 years of age in the highest serum cholesterol quartile was 1.5 (95% CI, 1.2 to 2.0) compared with those in the three lower quartiles combined. The relative risk did not change greatly with age, ranging from 1.4 in men 60 to 64 years of age to 1.7 in men 75 to 79 years of age. However, because mortality from coronary heart disease increased with age, the excess risk for such mortality attributable to elevated serum cholesterol levels increased fivefold over these 20 years, from 2.2 deaths per 1000 person-years to 11.3 deaths per 1000 person-years.

Conclusions: Our results support those of other observational studies in elderly men. If treatment of high blood cholesterol is as effective in reducing cholesterol-related risk for coronary heart disease after 65 years of age as it is in middle-aged men, it might actually produce greater reductions in mortality due to coronary heart disease. A clinical trial is needed to confirm this extrapolation.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)