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Effects of Different Calcium Antagonists on Proteinuria Associated with Diabetes Mellitus

Bryan K. Demarie, MD; and George L. Bakris, MD
[+] Article, Author, and Disclosure Information

Grant Support: By grants from the American Diabetes Association, Louisiana affiliate, and the Alton Ochsner Medical Foundation.

Requests for Reprints: George L. Bakris, MD, Ochsner Medical Institutions, Section on Nephrology, 1514 Jefferson Highway, New Orleans, LA 70121.

Current Author Addresses: Dr. Demarie: Ochsner Foundation Hospital, 1516 Jefferson Highway, New Orleans, LA 70121.

Dr. Bakris: Ochsner Medical Institutions, Section on Nephrology, 1514 Jefferson Highway, New Orleans, LA 70121.

Ann Intern Med. 1990;113(12):987-988. doi:10.7326/0003-4819-113-12-987
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This excerpt has been provided in the absence of an abstract.

Studies in various animal models of renal dysfunction show that urinary protein excretion is partly determined by glomerular capillary pressure (1-5). Further, clinical studies have shown that nifedipine, an agent that does not alter glomerular capillary pressure, increases urinary protein excretion and leads to renal dysfunction (6-8). In addition, diltiazem, an agent that lowers glomerular capillary pressure, decreases urinary protein excretion in a manner similar to that of angiotensin-converting enzyme inhibitors in diabetic patients with renal insufficiency and hypertension (9). We conducted a prospective crossover trial to evaluate the effects of diltiazem and nifedipine on urinary protein excretion in diabetic,


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