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AIDS Vaccines: Progress and Unmet Challenges

Dani P. Bolognesi, PhD
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Requests for Reprints: Dani P. Bolognesi, PhD, P.O. Box 2926, Duke University Medical Center, Durham, NC 27710.

Duke University Medical Center
Durham, NC 27710

Ann Intern Med. 1991;114(2):161-162. doi:10.7326/0003-4819-114-2-161
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Historically, vaccines have proved to be the most effective, most economical, and safest means of controlling infectious diseases in animals and humans. Indeed, among the most resounding triumphs in medicine has been the development of successful vaccines against viruses, notably those against smallpox and polio. To date, the biomedical community has had no greater challenge than to develop a vaccine against the human immunodeficiency virus (HIV), a virus that presents unprecedented obstacles to researchers and vaccinologists alike. Although the development of a vaccine for the acquired immunodeficiency syndrome (AIDS) has appeared to be a remote prospect, recent progress along several



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