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Omeprazole Enhances the Efficacy of Pancreatin (Pancrease) in Cystic Fibrosis

Harry G. Heijerman, MD; Cornelis B. Lamers, MD; and Willem Bakker, MD
[+] Article and Author Information

Current Author Addresses: Drs. Heijerman and Bakker: Adult Cystic Fibrosis Centre, Department of Pulmonology, Leyenburg Hospital, The Hague, The Netherlands.

Dr. Lamers: Department of Gastroenterology, University Hospital, Leiden, The Netherlands.


© 1991 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1991;114(3):200-201. doi:10.7326/0003-4819-114-3-200
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We studied the effect of the addition of omeprazole (20 mg once a day) to treatment with pancreatin (Pancrease, Cilag, Herentals, Belgium), two or four capsules three times a day, on fecal fat excretion in a double-blind, crossover fashion in nine patients with cystic fibrosis having persistent steatorrhea while taking Pancrease, two capsules three times a day (mean fecal fat excretion, 22.3%; range, 12% to 44%). Neither doubling of the dose of Pancrease nor addition of omeprazole to the lower dose of Pancrease significantly reduced fecal fat excretion (mean, 19.6% [range, 10% to 34%]; mean, 16.4% [range, 6% to 32%], respectively). However, addition of omeprazole to the higher dose of Pancrease (four capsules three times a day) significantly reduced fecal fat excretion when compared with the two doses of Pancrease alone (mean, 10.7%; range, 4% to 25%; P < 0.01). We conclude that adjunct therapy with omeprazole reduces fecal fat excretion in cystic fibrosis provided that a high dose of Pancrease is supplied.

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