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Barrett Esophagus after Chemotherapy with Cyclophosphamide, Methotrexate, and 5-Fluorouracil (CMF): An Iatrogenic Injury?

Sergio Sartori, MD; Ingrid Nielsen, MD; Monica Indelli, MD; Lucio Trevisani, MD; Paolo Pazzi, MD; and Enrico Grandi, MD
[+] Article, Author, and Disclosure Information

Requests for Reprints: Sergio Sartori, MD, II Department of Medicine and Oncology Service, St. Anna General Hospital, corso Giovecca 203, 44100 Ferrara, Italy.

Current Author Addresses: Drs. Sartori, Nielsen, Indelli, Trevisani, and Pazzi: St. Anna General Hospital, corso Giovecca 230, 44100 Ferrara, Italy.

Dr. Grandi: Pathology Institute, University of Ferrara, 44100 Ferrara, Italy.

Ann Intern Med. 1991;114(3):210-211. doi:10.7326/0003-4819-114-3-210
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This excerpt has been provided in the absence of an abstract.

In Barrett esophagus, the squamous mucosa of the lower esophagus is replaced by columnar epithelium (1). This metaplastic disorder can result from a congenital abnormality, but more frequently results from gastroesophageal reflux (1, 2).

In 1987, Dahms and colleagues (3) observed Barrett esophagus in three children who had been treated with antileukemia chemotherapy and suspected that Barrett esophagus could result from chemotherapy-induced esophageal mucosal injury. We recently reported six cases of Barrett esophagus in eight women who had been treated with several courses of chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) for breast cancer (Sartori S. Communication at "The Holland


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