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Hypertension Associated with Endothelin-Secreting Malignant Hemangioendothelioma

Koji Yokokawa, MD; Hideki Tahara, MD; Masakazu Kohno, MD; Koh-ichi Murakawa, MD; Kenichi Yasunari, MD; Koichi Nakagawa, MD; Toshio Hamada, MD; Shuzo Otani, MD; Masashi Yanagisawa, MD; and Tadanao Takeda, MD
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Requests for Reprints: Koji Yokokawa, MD, First Department of Internal Medicine, Osaka City University Medical School, 1-5-7 Asahimachi, Abeno-ku, Osaka 545, Japan.

Current Author Addresses: Drs. Yokokawa, Kohno, Murakawa, Yasunari, and Takeda: First Department of Internal Medicine, Osaka City University Medical School, 1-5-7 Asahi-machi, Abeno-ku, Osaka 545, Japan.

Drs. Tahara and Otani: Second Department of Biochemistry, Osaka City University Medical School, 1-4-54 Asahi-machi, Abeno-ku, Osaka 545, Japan.

Drs. Nakagawa and Hamada: Department of Dermatology, Osaka City University Medical School, 1-5-7 Asahi-machi, Abeno-ku, Osaka 545, Japan.

Dr. Yanagisawa: Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan.

Ann Intern Med. 1991;114(3):213-215. doi:10.7326/0003-4819-114-3-213
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This excerpt has been provided in the absence of an abstract.

Endothelin-1, a potent vasoconstrictor peptide that has recently been isolated from the supernatant of cultured porcine aortic endothelial cells (1), is involved in some vascular disorders (2). Malignant hemangioendothelioma, a rare malignant vascular neoplasm, is characterized by intravascular proliferation of atypical endothelium. Patients with malignant hemangioendothelioma usually die with metastases to the lungs and brain or with vascular involvement in the brain or coronary arteries (3). We measured plasma levels of endothelin-1 in two patients with malignant hemangioendothelioma of the scalp before and after surgical excision.

Materials and Methods: Endothelin-1 was extracted from EDTA-plasma or prepared tissue samples (4) through


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