The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Lymphoproliferative Responses to Borrelia burgdorferi in Lyme Disease

David C. Zoschke, MD, PhD; Archibald A. Skemp, MD; and Dana L. Defosse, BS
[+] Article, Author, and Disclosure Information

Grant Support: In part by National Institutes of Health grant 5R01-AR-33492.

Requests for Reprints: David C. Zoschke, MD, Department of Medicine, Section of Rheumatology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455.

Current Author Addresses: Drs. Zoschke and Skemp and Mr. Defosse: Department of Medicine, Section of Rheumatology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455.

© 1991 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1991;114(4):285-289. doi:10.7326/0003-4819-114-4-285
Text Size: A A A

Objective: To compare lymphocyte proliferative responses to Borrelia burgdorferi in healthy controls and patients with Lyme disease.

Patients: Twelve patients fulfilling case-definition criteria for Lyme disease. Twelve healthy volunteers and two newborns served as controls.

Measurements: Antibodies to B. burgdorferi were measured by enzyme-linked immunosorbent assay (ELISA). Proliferation of peripheral blood lymphocytes cultured for 5 days with B. burgdorferi, recall antigens, or pokeweed mitogen was measured by radioactive thymidine uptake.

Results: Lymphocytes from 11 patients with Lyme disease, 8 healthy seronegative controls, and two newborns showed elevated responses when stimulated with B. burgdorferi. When a patient and a control were studied on the same day, the patient's lymphocyte response to B. burgdorferi exceeded the control's in only 5 of 12 cases. Lymphocytes from both patients and controls responded to B. burgdorferi isolates from three different sources.

Conclusions: Heightened lymphocyte responses to B. burgdorferi are found in patients with Lyme disease but elevated responses also frequently occur in healthy controls. At present, the interpretation of a positive lymphocyte response to B. burgdorferi would be difficult in ambiguous clinical situations.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.