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Immunogenicity of an Inactivated Hepatitis A Vaccine

Maria H. Sjogren, MD, MPH; Charles H. Hoke, MD; Leonard N. Binn, PhD; Kenneth H. Eckels, PhD; Doria R. Dubois, PhD; Lionel Lyde; Amy Tsuchida, MD; Stanley Oaks Jr., PhD; Ruth Marchwicki, BS; Wayne Lednar, MD, PhD; Robert Chloupek, MD; John Ticehurst, MD; and William H. Bancroft, MD
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Requests for Reprints: Maria H. Sjogren, MD, MPH, Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100.

Current Author Addresses: Drs. Sjogren, Hoke, Binn, Eckels, Dubois, and Ticehurst, Mr. Lyde, and Ms. Marchwicki: Walter Reed Army Institute of Research, Washington, D.C. 20307-5100.

Dr. Tsuchida: Department of Gastroenterology, Fort Lewis, WA 98433.

Dr. Oaks: Institute of Medicine, National Academy of Sciences, 2101 Constitution Avenue, NW, Washington, D.C. 20418.

Dr. Lednar: Building 320, Eastman-Kodak, Kodak Park Company, Rochester, NY 14652-3615.

Dr. Chloupek: HQ, Forces Command (FCMD), Fort McPherson, GA 30330-6000.

Dr. Bancroft: HQ, VSAMRDC, SGRD-PLA, Fort Detrick, Frederick, MD 21702-5012.

Ann Intern Med. 1991;114(6):470-471. doi:10.7326/0003-4819-114-6-470
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This excerpt has been provided in the absence of an abstract.

Although hepatitis A is a disease without chronic sequelae, it is associated with serious morbidity in adults. An inactivated hepatitis A vaccine prepared at the Walter Reed Army Institute of Research was observed to successfully immunize owl monkeys (1). In a preliminary study, this vaccine was given to eight men, all of whom developed neutralizing antibody to hepatitis A virus (anti-HAV) (2). The present study was designed to confirm the vaccine's immunogenicity, to obtain additional evidence of vaccine safety, and to establish a practical dosing schedule.

Methods: Forty-two male volunteers, 18 to 50 years of age, were enrolled from among


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