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Mycosis Fungoides Arthropathy

Robert G. Berger, MD; Susan J. Knox, MD, PhD; Ronald Levy, MD; Jeffrey L. Sklar, MD, PhD; Philip Cohen, MD; and Thomas Reichert, MD, PhD
[+] Article, Author, and Disclosure Information

Requests for Reprints: Robert G. Berger, MD, Division of Rheumatology & Immunology, University of North Carolina, Chapel Hill School of Medicine, Campus Box 7280, Chapel Hill, NC 27599-7280.

Current Author Addresses: Drs. Berger and Cohen: Division of Rheumatology & Immunology, University of North Carolina, Chapel Hill School of Medicine, Campus Box 7280, Chapel Hill, NC 27599-7280.

Drs. Knox and Levy: Department of Radiation Oncology, Stanford University Hospital, Stanford, CA 94305.

Dr. Sklar: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115.

Dr. Reichert: Becton-Dickinson, One Becton Drive, Franklin Lakes, NJ 07417.

Ann Intern Med. 1991;114(7):571-572. doi:10.7326/0003-4819-114-7-571
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This excerpt has been provided in the absence of an abstract.

We report the case of a patient with mycosis fungoides who developed a progressive arthropathy from malignant synovial infiltration. The arthropathy responded to treatment with a chimeric, human-murine monoclonal antibody against T-helper cells.

Case Report: At 39 years of age, this previously healthy woman developed a rash over her abdomen and, subsequently, over her thighs and arms. The rash was characterized by hyperkeratotic, erythematous plaques. Two years later, she developed a symmetric, nonerosive small hand-joint arthritis. Tests for rheumatoid factor and antinuclear antibody had negative results.Over the next year, the patient's rheumatic and cutaneous symptoms responded to neither hydroxychloroquine


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