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Coronary Angiography after Thrombolytic Therapy for Acute Myocardial Infarction

Eric J. Topol, MD; David R. Holmes, MD; and William J. Rogers, MD
[+] Article, Author, and Disclosure Information

Grant Support: In part by grant HL38529-01 from the National Heart, Lung and Blood Institute.

Requests for Reprints: Eric J. Topol, MD, Division of Cardiology, B1-F245, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0022.

Current Author Addresses: Dr. Topol: Division of Cardiology, B1-F245, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0022.

Dr. Holmes: Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55902.

Dr. Rogers: 334 LHR Building, Department of Medicine, University of Alabama Medical Center, Birmingham, AL 35294.

© 1991 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1991;114(10):877-885. doi:10.7326/0003-4819-114-10-877
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This excerpt has been provided in the absence of an abstract.

Purpose: To review the status of emergency, urgent, routine, and selective angiography after intravenous thrombolytic therapy.

Data Sources: Relevant English-language articles published from January 1985 to July 1990 were identified through MEDLINE.

Study Selection: For emergency angiography, four major randomized studies were reviewed and data from nine studies that incorporated rescue coronary angioplasty were pooled for metaanalysis. For urgent angiography, two controlled trials were reviewed. Comparisons of routine and selective angiography were done using data from two dedicated, large-scale, controlled trials and the ancillary findings of four other studies of reperfusion that incorporated angiography.

Data Extraction: The review emphasizes the findings from multicenter, randomized, controlled trials.

Data Synthesis: Emergency coronary angiography is done pri marily in preparation for primary or rescue angioplasty; the value of rescue angioplasty has yet to be assessed in a randomized trial, but technical success and reocclusion improve significantly after therapy with nonspecific plasminogen activators compared with relatively specific agents (success rate, 86% compared with 75%, respectively; P = 0. 03; reocclusion rate, 10.9% compared with 26.8%, respectively; P < 0.001). Urgent coronary angiography has value for treating recurrent ischemia, but patients who develop this complication after thrombolysis are likely to have a suboptimal outcome despite aggressive care. Studies support the use of either selective or routine angiography in uncomplicated patients after thrombolytic therapy; either approach is acceptable, but the former is more practical and may prove to be cost effective.

Conclusions: Optimal follow-up for patients with evolving myocardial infarction who receive thrombolysis may incorporate coronary angiography at various stages. Although our ability to noninvasively detect reperfusion, reocclusion, or viable but ischemic myocardium is limited at present, available data may assist in selecting a catheterization strategy.


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