The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Acetaminophen Does Not Impair Clearance of Zidovudine

Fred R. Sattler, MD; Richard Ko, PharmD; Diana Antoniskis, MD; Mark Shields, MS; Jordan Cohen, PhD; John Nicoloff; John Leedom; and Robert Koda, PharmD, PhD
[+] Article, Author, and Disclosure Information

Grant Support: In part by contracts from the AIDS Clinical Trials Program of the National Institutes of Allergy and Infectious Diseases (NOI-AI-62540) and the California Collaborative Treatment Group of the State of California University-wide AIDS Research Program (RO-CC8650). Computational assistance was provided by the National Center for Research Resources of the General Clinical Research Centers CLINFO Project (MO1 RR-43).

Requests for Reprints: Fred R. Sattler, MD, Los Angeles County-University of Southern California Medical Center, 1175 North Cummings Street, 5P77N, Los Angeles, CA 90033.

Current Author Addresses: Drs. Sattler, Antoniskis, Nicoloflf, and Leedom: Los Angeles County-University of Southern California Medical Center, 1175 North Cummings Street, Los Angeles, CA 90033.

Dr. Ko: State of California Department of Health Services-FDB, 714 P. Street, Room 440, Sacramento, CA 95814.

Mr. Shields: University of Southern California School of Medicine, 2025 Zonal Avenue, Los Angeles, CA 90033.

Dr. Cohen: College of Pharmacy, University of Kentucky, Rose Street, Pharmacy Building, Lexington, KY 40536.

Dr. Koda: University of Southern California School of Pharmacy, 1985 Zonal Avenue, Room 200C, Los Angeles, CA 90033.

©1991 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1991;114(11):937-940. doi:10.7326/0003-4819-114-11-937
Text Size: A A A

Objective: To determine whether concurrent treatment with acetaminophen and zidovudine impairs clearance of zidovudine, thereby increasing the risk for zidovudine-induced hematologic toxicity.

Design: Dose escalation, drug interaction study.

Setting: University clinical research center.

Patients: Patients with the acquired immunodeficiency syndrome (AIDS) or advanced AIDS-related complex.

Interventions: Acetaminophen and 200 mg of zidovudine simultaneously every 4 hours. For 13 patients, the unit dosage of acetaminophen was 325 mg for 3 days; for 8 patients, the dosage was 650 mg for 3 days; and, for 6 patients, the dosage was 650 mg for 7 days.

Measurements: Zidovudine clearance and production of the glucuronide conjugate of zidovudine were assessed after acetaminophen treatment.

Main Results: Neither zidovudine clearance nor production of the glucuronide conjugate of zidovudine was impaired after treatment with acetaminophen. Clearance of zidovudine was actually accelerated by 5%, 11%, and 33% with the three acetaminophen regimens, respectively (P = 0.002 by analysis of variance; P = 0.04 for linear trend when changes in the area-under-the-curve for zidovudine were compared).

Conclusion: Because serum concentrations of zidovudine decrease after the coadministration of acetaminophen, a pharmacokinetic interaction between zidovudine and acetaminophen is unlikely to increase the risk for hematologic toxicity associated with zidovudine.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.