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Autotransplantation in Lymphoma: Better Therapy or Healthier Patients?

Antonella Surbone, MD; James O. Armitage, MD; and Robert Peter Gale, MD, PhD
[+] Article, Author, and Disclosure Information

Grant Support: In part by grant CA 23175 from the NCI, NIH, USPHS, DHHS and by the Center for Advanced Studies in Leukemia. Robert Peter Gale is the Wald Foundation Scholar in Biomedical Communication and President of the Center for Advanced Studies in Leukemia.

Requests for Reprints: Robert Peter Gale, MD, PhD, Department of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90024-1678.

Memorial Sloan-Kettering Cancer Center
New York, NY 10021University of Nebraska Medical Center
Omaha, NE 68198-3332UCLA School of Medicine Los Angeles
CA 90024-1678

Ann Intern Med. 1991;114(12):1059-1060. doi:10.7326/0003-4819-114-12-1059
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Although some persons with large-cell lymphoma are cured with chemotherapy, most are not. In persons failing to achieve an initial remission and in those relapsing, rescue is generally attempted with further chemotherapy or, in some cases, radiation. Unfortunately, results of rescue therapy are poor. Recently, in an attempt to improve this situation, very high doses of chemotherapy or radiotherapy (or both) were administered followed by an autotransplant of previously stored hematopoietic stem cells from bone marrow or blood. Early reports suggested a higher cure rate with the more intensive therapy that autotransplantation allowed.

There is now widespread interest in autotransplantation





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