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Fluconazole Treatment of Persistent Cryptococcus neoformans Prostatic Infection in AIDS

Samuel A. Bozzette, MD; Robert A. Larsen, MD; Joseph Chiu, MD; Mary Ann E. Leal, MD; Jeremiah G. Tilles, MD; Douglas D. Richman, MD; John M. Leedom, MD; and J. Allen McCutchan, MD
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Grant Support: By the California Collaborative Treatment Group of the California Universitywide AIDS Research Program. Fluconazole was supplied by Pfizer Central Research, Groton, Connecticut.

Requests for Reprints: Samuel A. Bozzette, MD, Division of Infectious Diseases, University of California San Diego Medical Center, H-208, 225 Dickinson Street, San Diego, CA 92103.

Current Author Addresses: Drs. Bozzette and McCutchan: Division of Infectious Diseases, University of California San Diego Medical Center, H-208, 225 Dickinson Street, San Diego, CA 92103.

Drs. Larsen and Leal: Pediatric Pavilion, USC-LAC Medical Center, Room 2E10, 1129 North State Street, Los Angeles, CA 90033.

Drs. Chiu and Tilles: University of California Irvine Medical Center, Building 53, Route 81, 101 City Drive South, Orange, CA 92668.

Dr. Richman: Infectious Diseases, 111F, Veterans Affairs Medical Center, 3300 La Jolla Village Drive, San Diego, CA 92181.

Dr. Leedom: Infectious Diseases, USC-LAC Medical Center, Room 6442, 1200 North State Street, Los Angeles, CA 90033.

Ann Intern Med. 1991;115(4):285-286. doi:10.7326/0003-4819-115-4-285
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This excerpt has been provided in the absence of an abstract.

The prostate gland is a common site for persistent and recurrent Cryptococcus neoformans infection after amphotericin B therapy for cryptococcal meningitis in patients with the acquired immunodeficiency syndrome (AIDS) (1, 2). Additional prolonged amphotericin B therapy up to total doses of six grams has not led to suppression of cryptococcuria, and discontinuation of therapy has led to recurrence of disseminated infection (1 and unpublished data). In seeking more effective therapies, we prospectively studied patients treated with fluconazole, an orally absorbed triazole that has excellent tissue penetration and antifungal activity in cryptococcal infection (2-5).

Patients and Methods: We studied 14 patients


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