The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

The Optimal Timing of Mastectomy: Low Tide or High Tide?

William L. McGuire, MD
[+] Article, Author, and Disclosure Information

Requests for Reprints: William L. McGuire, MD, University of Texas Health Science Center, Division of Medical Oncology, 7703 Floyd Curl Drive, San Antonio, TX 78284-7884.

University of Texas Health Science Center
San Antonio, TX 78284-7884

Ann Intern Med. 1991;115(5):401-403. doi:10.7326/0003-4819-115-5-401
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Frankly, I have been skeptical about the claims of chronobiologists that many important biologic phenomena in humans are regulated in no small way by earthly rhythms. These might include time of day or month, light and dark, phases of the moon, ocean tides, and so forth. As you can imagine, my interest was piqued when Hrushesky and colleagues published their provocative study of 41 premenopausal patients with breast cancer demonstrating that mastectomy done during the perimenstrual period (days 0 to 6 and 21 to 36 from the start of the last menstrual period) was associated with a higher subsequent recurrence




First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.