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Editorials |

Management of Septic Shock: Present and Future

Joseph E. Parrillo, MD
[+] Article and Author Information

Requests for Reprints: Joseph E. Parrillo, MD, Sections of Cardiology and Critical Care Medicine, Rush-Presbyterian-St. Luke's Medical Center, 1653 West Congress Parkway, Room 1021-Jelke, Chicago, IL 60612.

Current Author Address: Dr. Parrillo: Sections of Cardiology and Critical Care Medicine, Rush-Presbyterian-St. Luke's Medical Center, 1653 West Congress Parkway, Room 1021-Jelke, Chicago, IL 60612.


Rush-Presbyterian-St. Luke's Medical Center
Chicago, IL 60612


Ann Intern Med. 1991;115(6):491-493. doi:10.7326/0003-4819-115-6-491
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This excerpt has been provided in the absence of an abstract.

Sepsis and septic shock have been increasing in incidence for the last 60 years, and sepsis is presently the most common cause of death in intensive care units in the United States. Reasonable current estimates of annual incidence are 400 000 bouts of sepsis, 200 000 cases of septic shock, and 100 000 deaths from this disease (1). The reasons for this rising incidence include increased use of invasive devices such as intravascular and bladder catheters, more frequent corticosteroid and cytotoxic therapy, and enhanced longevity of patients (for example, patients with diabetes) who are susceptible to sepsis.

The overall mortality

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septic shock

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