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Disseminated Intravascular Coagulation after Factor IX Complex Resolved Using Purified Factor IX Concentrate

Terence Hadley, MD; and Benjamin Djulbegovic, MD, PhD
[+] Article and Author Information

Requests for Reprints: Benjamin Djulbegovic, MD, PhD, University of Louisville, Department of Medicine, Division of Medical Oncology/ Hematology, James Graham Brown Cancer Center, 529 South Jackson Street, Louisville, KY 40292.

Current Author Addresses: Drs. Hadley and Djulbegovic: University of Louisville, Department of Medicine, Division of Medical Oncology/ Hematology, James Graham Brown Cancer Center, 529 South Jackson Street, Louisville, KY 40292.


Ann Intern Med. 1991;115(8):621-622. doi:10.7326/0003-4819-115-8-621
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This excerpt has been provided in the absence of an abstract.

Patients with hemophilia B can be effectively treated with prothrombin complex concentrates (factor IX complex) that contain factors II, VII, IX, and X (1). A complication of therapy with factor IX complex is disseminated intravascular coagulation, attributed in part to activated factors in factor IX complex (2). We describe a patient with hemophilia B who developed disseminated intravascular coagulation while being treated with factor IX complex for a cerebellar hemorrhage. The patient's therapy was switched from factor IX complex to monoclonal antibody-purified factor IX (Mononine, Armour, Blue Bell, Pennsylvania), and the disseminated intravascular coagulation resolved.

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