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Ceftriaxone-induced Cholelithiasis

Alvaro J. Lopez, MD; Paul O'Keefe, MD; Marilynn Morrissey; and Jack Pickleman, MD
[+] Article, Author, and Disclosure Information

Requests for Reprints: Paul O'Keefe, MD, Section of Infectious Diseases, Loyola University of Chicago, 2160 South First Avenue, Maywood, IL 60153.

Current Author Addresses: Dr. Lopez: 1459 Montreal Road, Suite 506, Tucker, GA 30084.

Drs. O'Keefe, Morrissey, and Pickleman: Loyola University of Chicago, 2160 South First Avenue, Maywood, IL 60153.

Ann Intern Med. 1991;115(9):712-714. doi:10.7326/0003-4819-115-9-712
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This excerpt has been provided in the absence of an abstract.

Gallbladder sludge formation has been reported as a unique complication of therapy with ceftriaxone. We report the first patient with proven ceftriaxone-induced cholelithiasis in which the drug was identified as the major component of the gallstone.

Case Report: A 42-year-old man had a history of rheumatic heart disease and of chronic active hepatitis for which he was receiving prednisone. Between September 1989 and February 1990 he had three episodes of infective endocarditis with Salmonella group C1 (Salmonella choleraesuis). Each episode of endocarditis was treated with a prolonged (minimum, 7 weeks) course of intravenous ceftriaxone, 2 g every 12 hours, and


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