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Chemotherapy Combined with Chest Irradiation for Locally Advanced Non-Small Cell Lung Cancer: The End of the Beginning?

Daniel C. Ihde, MD
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Requests for Reprints: Daniel C. Ihde, MD, Office of the Director, Building 31, Room 11A48, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892.

National Cancer Institute
Bethesda, MD 20892

Ann Intern Med. 1991;115(9):737-739. doi:10.7326/0003-4819-115-9-737
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This excerpt has been provided in the absence of an abstract.

Lung cancer is the second most common cancer and the most common fatal cancer in the United States (2). Three fourths of these malignancies are pathologically diagnosed as squamous, large cell, or adenocarcinoma. These histologic subtypes are often viewed as a single entity, non-small cell lung cancer, because they exhibit similar biologic behavior. In contrast to small-cell carcinoma, they often present as sufficiently localized neoplasms that may be approached surgically with curative intent but are relatively unresponsive to cytotoxic chemotherapy.

Between one fourth and one third of patients with non-small cell lung cancer do not have clinically detectable distant metastatic


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