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Increasing the Dietary Potassium Intake Reduces the Need for Antihypertensive Medication

Alfonso Siani, MD; Pasquale Strazzullo, MD; Angela Giacco, RD; Delia Pacioni, RD; Egidio Celentano, MD; and Mario Mancini, MD
[+] Article and Author Information

Requests for Reprints: Pasquale Strazzullo, MD, Institute of Internal Medicine & Metabolic Diseases, 2nd Medical School, University of Naples, Via S. Pansini 5-80131, Naples, Italy.

Current Author Addresses: Drs. Siani, Strazzullo, Celentano, and Mancini, Ms. Giacco, and Ms. Pacioni: Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, via S. Pansini, 5-80131 Naples, Italy.


© 1991 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1991;115(10):753-759. doi:10.7326/0003-4819-115-10-753
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Objective: To determine whether an increase in dietary potassium intake from natural foods reduces the need for antihypertensive medication in patients with essential hypertension.

Design: Randomized, controlled trial with 1-year follow-up.

Setting: Hypertension outpatient clinic of a university hospital.

Patients: Fifty-four patients with well-controlled hypertension, 47 of whom completed 1 year of follow-up.

Intervention: Patients were randomly assigned to one of two groups and were given dietary advice aimed at selectively increasing potassium intake (group 1) or at keeping their customary diet unchanged (group 2). During a 1-year follow-up period, drug therapy was reduced in stepwise fashion, according to a fixed protocol, provided that blood pressure remained below 160/95 mm Hg.

Main Results: Potassium intake was checked monthly by referring to 3-day food records and by measuring 24-hour urinary potassium excretion. Potassium intake increased in group 1 but did not change in group 2 (P < 0.001). No change was observed in either urinary sodium excretion or in body weight. After 1 year, the average drug consumption (number of pills per day) relative to that at baseline was 24% in group 1 (95% Cl, 15% to 32%) and 60% in group 2 (Cl, 44% to 76%) (P < 0.001). By the end of the study, blood pressure could be controlled using less than 50% of the initial therapy in 81% of the patients in group 1 (Cl, 66% to 96%) compared with 29% of the patients in group 2 (Cl, 10% to 48%) (P = 0.001). Patients in group 1 ended the study with a lower number of reported symptoms compared with patients in the control group (P < 0.001).

Conclusion: Increasing the dietary potassium intake from natural foods is a feasible and effective measure to reduce antihypertensive drug treatment.

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