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Treatment of Rheumatoid Arthritis: Challenges to Traditional Paradigms

Theodore Pincus, MD; and Frederick Wolfe, MD
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Requests for Reprints: Theodore Pincus, MD, Department of Medicine, Division of Rheumatology and Immunology, T-3219 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232.

Vanderbilt University School of Medicine
Nashville, TN 37232University of Kansas School of Medicine
Wichita, KS 67214

Ann Intern Med. 1991;115(10):825-827. doi:10.7326/0003-4819-115-10-825
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Gold treatment for rheumatoid arthritis has evoked controversy in this journal for at least half a century. In 1942, Cecil and colleagues stated that "in disagreement with Snyder and his co-workers (1) who say that gold treatment should be undertaken only when the arthritis is refractory to every other form of treatment . . . gold salts are most effective in the treatment of early cases (2). . . ." The tradition of controversy in the Annals concerning gold salts was most recently expressed in the report by Epstein and colleagues (3), which suggested that this treatment appeared of no


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