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Effects of Long-term Sulindac Therapy on Colonic Polyposis

Joaquim Rigau, MD; Josep M. Piqué, MD; Elisa Rubio, MD; Ramón Planas, MD; Josep M. Tarrech, MD; and Josep M. Bordas, MD
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Grant Support: In part by Fundació Catalana per les Malaties del Fetge i Gastroenterològiques.

Requests for Reprints: Josep M. Piqué, MD, Gastroenterology Department, Hospital Clínic, Barcelona University, Villarroel 170, 08036 Barcelona, Spain.

Current Author Addresses: Drs. Rigau, Rubio, and Tarrech: Hospital General de Granollers, Departments of Medecine and Surgery, Granollers, Barcelona, Spain.

Drs. Piqué and Bordas: Hospital Clínic, Barcelona University, Gastroenterology Department, Villarroel 170, 08036 Barcelona, Spain.

Dr. Planas: Hospital Germans Trias i Pujol, Gastroenterology Department, Crta. Cañet, Badalona, Barcelona, Spain.

Ann Intern Med. 1991;115(12):952-954. doi:10.7326/0003-4819-115-12-952
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Sulindac treatment has been reported to induce marked reductions in the number and size of adenomatous polyps in the rectal segment after subtotal colectomy (1). These findings were not conclusive, however, because spontaneous remission of rectal adenomas after colectomy and ileorectal anastomosis has been described in patients with familial polyposis (2). Gonzaga and co-workers (3) and Wadell and associates (4) have described patients for whom sulindac treatment has led to a decrease in diffuse adenomatous polyps in intact colons. We report our experience with seven patients having diffuse colonic polyposis treated with sulindac. Endogenous prostaglandin generation in the colonic mucosa


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