The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

Obesity at Diagnosis of Breast Carcinoma Influences Duration of Disease-free Survival

Ruby T. Senie, PhD; Paul Peter Rosen, MD; Philip Rhodes, MS; Martin L. Lesser, PhD; and David W. Kinne, MD
[+] Article, Author, and Disclosure Information

Presented in part at the 14th Annual Meeting of the American Society of Preventive Oncology, 19 March 1990, Bethesda, Maryland.

Requests for Reprints: Ruby T. Senie, PhD, Women's Health and Fertility Branch, Division of Reproductive Health, Centers for Disease Control, 1600 Clifton Road, Atlanta, GA 30333.

Current Author Addresses: Dr. Senie and Mr. Rhodes: Centers for Disease Control, 1600 Clifton Road, Atlanta, GA 30333.

Dr. Rosen and Dr. Kinne: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021.

Dr. Lesser: North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030.

Ann Intern Med. 1992;116(1):26-32. doi:10.7326/0003-4819-116-1-26
Text Size: A A A

Objective: To study disease-free survival at 10 years in relation to obesity at the time of diagnosis.

Design: A prospective study of consecutively treated patients with primary breast cancer.

Setting: Memorial Sloan-Kettering Cancer Center, New York.

Patients: Nine hundred twenty-three women treated by mastectomy and axillary dissection.

Main Results: Women who were obese (25% or more over optimal weight for height) at the time of primary breast cancer treatment were at significantly greater risk for recurrence (42%) compared with nonobese patients (32%) 10 years after diagnosis (P <0.01). In multivariate analyses, obesity remained a statistically significant prognostic factor after controlling for measured tumor size, number of positive axillary lymph nodes, age at diagnosis, and adjuvant chemotherapy with a hazard ratio of 1.29 (95% Cl, 1.0 to 1.67). When analyses were restricted to the 557 patients free of lymph node metastases, the hazard ratio of recurrence associated with obesity was 1.59 (Cl, 1.06 to 2.39); 32% of obese patients developed recurrent disease compared with 19% of nonobese women.

Conclusions: Obesity at the time of diagnosis is a significant prognostic factor that may limit the reduction in breast cancer mortality attainable through detection at an early stage of disease. Because obesity and the risk for breast cancer increase with age, interventions that encourage weight control may influence breast cancer survival rates.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.