0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Ideas and Opinions |

A Consumer's Guide to Subgroup Analyses

Andrew D. Oxman, MD; and Gordon H. Guyatt, MD
[+] Article and Author Information

Grant Support: In part by the Ontario Ministry of Health. Dr. Guyatt is a career scientist of the Ontario Ministry of Health.

Requests for Reprints: Andy Oxman, MD, Department of Family Medicine, McMaster University, Health Sciences Centre, Room 2V10, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5.

Current Author Addresses: Dr. Oxman: Department of Family Medicine, McMaster University, Health Sciences Centre, Room 2V10, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5.

Dr. Guyatt: Department of Clinical Epidemiology and Biostatistics, McMaster University, Health Sciences Centre, Room 2C12, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5.


© 1992 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1992;116(1):78-84. doi:10.7326/0003-4819-116-1-78
Text Size: A A A

▪ The extent to which a clinician should believe and act on the results of subgroup analyses of data from randomized trials or meta-analyses is controversial. Guidelines are provided in this paper for making these decisions. The strength of inference regarding a proposed difference in treatment effect among subgroups is dependent on the magnitude of the difference, the statistical significance of the difference, whether the hypothesis preceded or followed the analysis, whether the subgroup analysis was one of a small number of hypotheses tested, whether the difference was suggested by comparisons within or between studies, the consistency of the difference, and the existence of indirect evidence that supports the difference. Application of these guidelines will assist clinicians in making decisions regarding whether to base a treatment decision on overall results or on the results of a subgroup analysis.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)