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Low-Dose Splenic Irradiation in the Treatment of Autoimmune Thrombocytopenia in HIV-infected Patients

Samuel W. Needleman, MD; James Sorace, MD; and Hipolito Poussin-Rosillo, MD
[+] Article, Author, and Disclosure Information

Grant Support: Dr. Needleman is the recipient of VA Research Career Development Award RA 1596.

Requests for Reprints: Samuel W. Needleman, MD, Medicine Service (111), Baltimore Department of Veterans Affairs Medical Center, 3900 Loch Raven Boulevard, Baltimore, MD 21218.

Current Author Addresses: Drs. Needleman and Sorace: Baltimore Department of Veterans Affairs Medical Center, 3900 Loch Raven Boulevard, Baltimore, MD 21218.

Dr. Poussin-Rosillo: Department of Radiation Oncology, University of Maryland Hospital, 22 S. Greene Street, Baltimore, MD 21201.

Ann Intern Med. 1992;116(4):310-311. doi:10.7326/0003-4819-116-4-310
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This excerpt has been provided in the absence of an abstract.

Autoimmune thrombocytopenic purpura (AITP) is one of many compli-cations associated with human immunodeficiency virus (HIV) type-1 infections (1, 2). Circulating immune complexes (3), antiplatelet antibodies (4, 5), and anti-idiotype antibody formation (6) have each been suggested to play a role in its pathogenesis.

Treatment of AITP in HIV-infected patients is difficult for two reasons. Established therapies for AITP (that is, corticosteroids) may be associated with an increased risk in patients with HIV infection because they superimpose an additional immunosuppressive burden and thus might increase the rate of opportunistic infection (7). Splenectomy, although offering remission rates in HIV-infected patients comparable to


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