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Graft-versus-Host Disease in a Liver Transplant Recipient

Robert H. Collins Jr., MD; Barry Cooper, MD; Afzal Nikaein, PhD; Goran Klintmalm, MD, PhD; and Joseph W. Fay, MD
[+] Article, Author, and Disclosure Information

Grant Support: By the Delta Delta Delta Sorority Fund.

Requests for Reprints: Robert H. Collins, Jr., MD, Bone Marrow Transplantation Research, Baylor University Medical Center, Dallas, TX 75246.

Current Author Addresses: Drs. Collins and Fay: Bone Marrow Transplantation Research, Baylor University Medical Center, Dallas, TX 75246.

Dr. Cooper: 3320 Live Oak, #600, Dallas, TX 75204.

Dr. Nikaein: Transplant Immunology, Baylor University Medical Center, Dallas, TX 75246.

Dr. Klintmalm: Transplant Surgery, Baylor University Medical Center, Dallas, TX 75246.

Ann Intern Med. 1992;116(5):391-392. doi:10.7326/0003-4819-116-5-391
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This excerpt has been provided in the absence of an abstract.

The classic requirements for graft-versus-host disease (GVHD) (1) exist in recipients of liver allografts: 1) The donor liver and recipient are histo-incompatible; 2) lymphocytes within the lymph nodes and lymphatics of the donor graft are capable of recognizing the recipient as foreign and reacting to the recipient (for example, hemolysis of ABO-incompatible erythrocytes by allograft-derived antibodies has been well described [2]); and 3) the recipient is receiving post-transplant immunosuppressive therapy that could conceivably prevent recipient immune cells from eliminating anti-recipient donor cells.

Despite the presence of immunosuppression, GVHD is believed to be a rare phenomenon in liver transplant patients; few


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