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New Macrolide Antibiotics: Azithromycin and Clarithromycin

Harold C. Neu, MD
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Current Author Address: Dr. Neu: College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032.

Columbia University
New York, NY 10032

Ann Intern Med. 1992;116(6):517-519. doi:10.7326/0003-4819-116-6-517
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Eythromycin, the prototype of the macrolide antibiotics, was first used to treat infections in 1952. It has been used to treat streptococcal pharyngitis in penicillin-allergic patients, Mycoplasma pneumoniae respiratory infections, Legionella infection, and cutaneous infections due to streptococci and staphylococci (1). Erythromycin has also been used to treat pneumococcal infection of the ears, sinuses, and chest. It has also been used as prophylaxis during dental procedures in patients with valvular heart disease to prevent endocarditis and as prophylaxis before colonic surgery to prevent postoperative infection. Except for hepatic toxicity with the estolate form and rare temporary deafness at high doses,


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