0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Weight Loss Reduces the Risk for Symptomatic Knee Osteoarthritis in Women: The Framingham Study

David T. Felson, MD, MPH; Yuqing Zhang, MB, MPH; John M. Anthony, BA, BS; Allan Naimark, MD; and Jennifer J. Anderson, PhD
[+] Article and Author Information

Grant Support: By NIH Arthritis Center Grant AR20613, and by a Clinical Sciences Grant from the Arthritis Foundation.

Requests for Reprints: David Felson, MD, MPH, A203, 80 East Concord Street, Boston, MA 02118.

Current Author Addresses: Drs. Felson, Zhang, and Anderson and Mr. Anthony: A203, 80 East Concord Street, Boston, MA 02118.

Dr. Naimark: Dept. of Radiology, University Hospital, 71 East Newton Street, Boston, MA 02118.


© 1992 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1992;116(7):535-539. doi:10.7326/0003-4819-116-7-535
Text Size: A A A

Objective: To evaluate the effect of weight loss in preventing symptomatic knee osteoarthritis in women.

Design: Cohort analytic study.

Setting: The Framingham Study, based on a sample of a defined population.

Patients: Women who participated in the Framingham Knee Osteoarthritis Study (1983 to 1985): Sixty-four out of 796 women studied had recent-onset symptomatic knee osteoarthritis (knee symptoms plus radiographically confirmed osteoarthritis) were compared with women without disease.

Measurements: Recalled date of symptom onset was used as the incident date of disease. Historical weight was defined as baseline body mass index up to 12 years before symptom onset. Change in body mass index was assessed at several intervals before the current examination. Odds ratios assessing the association between weight change and knee osteoarthritis were adjusted for age, baseline body mass index, history of previous knee injury, habitual physical activity level, occupational physical labor, smoking status, and attained education.

Results: Weight change significantly affected the risk for the development of knee osteoarthritis. For example, a decrease in body mass index of 2 units or more (weight loss, approximately 5.1 kg) over the 10 years before the current examination decreased the odds for developing osteoarthritis by over 50% (odds ratio, 0.46; 95% Cl, 0.24 to 0.86; P = 0.02). Among those women with a high risk for osteoarthritis due to elevated baseline body mass index (> 25), weight loss also decreased the risk (for 2 units of body mass index, odds ratio, 0.41 ; P = 0.02). Weight gain was associated with a slightly increased risk for osteoarthritis, which was not statistically significant.

Conclusion: Weight loss reduces the risk for symptomatic knee osteoarthritis in women.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)