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Esophageal Ulceration Related to Zalcitabine (ddC)

Amy S. Indorf, MD; and P. Samuel Pegram, MD
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Requests for Reprints: P. Samuel Pegram, MD, Section on Infectious Diseases, Bowman Gray School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042.

Current Author Addresses: Drs. Indorf and Pegram: Section on Infectious Diseases, Bowman Gray School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042.

Ann Intern Med. 1992;117(2):133-134. doi:10.7326/0003-4819-117-2-133
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This excerpt has been provided in the absence of an abstract.

Zalcitabine (dideoxycytidine, ddC) is an antiretroviral agent whose efficacy in the management of human immunodeficiency virus (HIV) infection is currently being studied. We report a case of recurrent esophageal ulceration in a patient taking zalcitabine.

Case Report: A 20-year-old white man with progressive HIV infection (CD4 lymphocyte count 50 cells/μL but no AIDS-defining illness) was enrolled in a randomized, double-blind study of zalcitabine compared with zidovudine on 7 June 1990. He had no history of esophageal or gastrointestinal disease before he entered the study. His only medications were clotrimazole troches and monthly aerosolized pentamidine. On 22 June the patient complained


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