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Multidrug-resistant Tuberculosis

Samuel W. Dooley, MD; William R. Jarvis, MD; William J. Marione, MD; and Dixie E. Snider Jr., MD, MPH
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Requests for Reprints: Samuel W. Dooley, MD, Centers for Disease Control, Mailstop E-10, 1600 Clifton Road NE, Atlanta, GA 30333.

Ann Intern Med. 1992;117(3):257-259. doi:10.7326/0003-4819-117-3-257
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As recently as 10 years ago, tuberculosis was rapidly disappearing from the United States. Reported cases of tuberculosis were decreasing an average of almost 6% each year, from over 84 000 cases in 1953 to 22 255 cases in 1984. Beginning in 1985, however, the decades-long decline in tuberculosis cases reversed dramatically, and from 1985 to 1991, an 18.4% increase was noted in reported cases (1) (Centers for Disease Control [CDC]. Unpublished data). One reason for this reversal is reactivation of latent tuberculous infection in persons infected with human immunodeficiency virus (HIV) (2, 3).

Against this background of the increasing


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