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Increased Incidence of Hodgkin Disease in Homosexual Men with HIV Infection

Nancy A. Hessol, MSPH; Mitchell H. Katz, MD; Jennifer Y. Liu, MPH; Susan P. Buchbinder, MD; Christopher J. Rubino, BS; and Scott D. Holmberg, MD, MPH
[+] Article and Author Information

Grant Support: In part by cooperative agreement number U64/ CCU900523-08 from the Centers for Disease Control, Atlanta, Georgia.

Requests for Reprints: Nancy A. Hessol, MSPH, AIDS Office, 25 Van Ness Avenue, Suite 500, San Francisco, CA 94102.

Current Author Addresses: Ms. Hessol, Dr. Katz, Ms. Liu, Dr. Buchbinder, and Mr. Rubino: AIDS Office, 25 Van Ness Avenue, Suite 500, San Francisco, CA 94102.

Dr. Holmberg: Division of HIV/AIDS, Center for Infectious Diseases, Centers for Disease Control, 1600 Clifton Road NE, Mail Stop E45, Atlanta, GA 30333.


Ann Intern Med. 1992;117(4):309-311. doi:10.7326/0003-4819-117-4-309
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Objective: To evaluate the incidence of Hodgkin disease and non-Hodgkin lymphoma among homosexual men infected with human immunodeficiency virus (HIV).

Design: Cohort study with computer-matched identification of participants with the Northern California Cancer Center registry. Population rate comparisons were made with data from the Surveillance, Epidemiology, and End Results (SEER) cancer registry.

Participants: The 6704 homosexual men in the San Francisco City Clinic Cohort study.

Measurements: Incidence of Hodgkin disease, non-Hodgkin lymphoma, HIV infection, and the acquired immunodeficiency syndrome (AIDS); calculation of sex and age-adjusted standardized morbidity ratios and attributable risk.

Results: Eight cases of Hodgkin disease and 90 cases of non-Hodgkin lymphoma were identified through computer matching among cohort members residing in the San Francisco Bay area from 1978 through 1989. Among the HIV-infected men, the age-adjustedstandardized morbidity ratio was 5.0 (95% Cl, 2.0 to 10.3) for Hodgkin disease and 37.7 (Cl, 30.3 to 46.7) for non-Hodgkin lymphoma. The excess risk attributable to HIV infection was 19.3 cases of Hodgkin disease per 100 000 person-years and 224.9 cases of non-Hodgkin lymphoma per 100 000 person-years.

Conclusion: An excess incidence of Hodgkin disease was found in HIV-infected homosexual men. Additional well-designed epidemiologic studies are needed to determine whether Hodgkin disease should be considered an HIV-related malignancy.

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