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Retinoid Therapy for Acute Promyelocytic Leukemia: A Coming of Age for the Differentiation Therapy of Malignancy

David R. Parkinson, MD; and Malcolm A. Smith, MD, PhD
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Requests for Reprints: David Parkinson, MD, Investigational Drug Branch, DCT/NCI, Room 715, Executive Plaza North, Bethesda, MD 20892.

Cancer Therapy Evaluation Program
National Cancer Institute
Bethesda, MD 20892

Ann Intern Med. 1992;117(4):338-340. doi:10.7326/0003-4819-117-4-338
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This excerpt has been provided in the absence of an abstract.

In this issue of Annals, Frankel and colleagues (1) describe a syndrome that developed in patients with acute promyelocytic leukemia during treatment with all-trans retinoic acid (1). The description of this dramatic syndrome provides an opportunity to review the larger significance of a remarkable new class of drugs, retinoids, and of differentiation therapy for malignancy.

The unfolding story of the use of retinoic acid for successful remission induction in patients with acute promyelocytic leukemia is instructive and is a confirmation of the coming of age of the differentiation therapy of malignancy. Long a goal of cancer therapists, it is


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