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Alcohol and Mortality

Arthur L. Klatsky, MD; Mary Anne Armstrong, MA; and Gary D. Friedman, MD
[+] Article, Author, and Disclosure Information

Requests for Reprints: Arthur L. Klatsky, MD, Kaiser Permanente Medical Center, Department of Medicine, 280 West MacArthur Boulevard, Oakland, CA 94611.

Current Author Addresses: Dr. Klatsky: Kaiser Permanente Medical Center, Department of Medicine, 280 West MacArthur Boulevard, Oakland, CA 94611.

Dr. Friedman and Ms. Armstrong: Kaiser Permanente Medical Care Program, Division of Research, 3451 Piedmont Avenue, Oakland, CA 94611.

©1992 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1992;117(8):646-654. doi:10.7326/0003-4819-117-8-646
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Objective: To study the relation between alcohol intake and mortality in a large ambulatory population with attention to causes of death and differences related to age, sex, race, and baseline risk.

Design: Prospective cohort study.

Setting: Prepaid comprehensive health care program facilities in Oakland and San Francisco, California.

Participants: Adults (n = 128 934) who supplied data at health evaluations between 1978 and 1985.

Measurements: Demographic data and health history were supplied using questionnaires. Death was ascertained by an automated linkage system and was individually validated. Relative risk for death at various levels of drinking was calculated by Cox proportional hazards models using lifelong nondrinkers as the reference and controlling for eight covariables.

Results: Heavier drinkers were at greater risk for death from noncardiovascular causes (relative risk at ≥ 6 drinks per day compared with no alcohol = 1.6, 95% Cl, 1.3 to 2.0) especially cirrhosis, unnatural death, and tobacco-related cancers. This alcohol-associated risk was higher in women (relative risk for death from all causes at ≥ 6 drinks per day = 2.2; Cl, 1.4 to 3.8) and younger persons (for persons < 50 years of age, relative risk for death from all causes at ≥ 6 drinks per day = 1.9; Cl, 1.3 to 2.9). Lighter drinkers were at lower risk for death from cardiovascular disease, especially coronary heart disease (relative risk at 1 to 2 drinks per day = 0.7; Cl, 0.6 to 0.9), independent of baseline risk, with the greatest reduction of risk in older persons. Lighter drinkers over 60 years of age also had a slightly lower risk for noncardiovascular death, but this finding was not independent of baseline coronary heart disease risk.

Conclusions: Women and younger persons appear more susceptible to the increased mortality risk of heavy drinking. The reduced cardiovascular risk of lighter drinkers is more pronounced in older persons. Lower coronary disease prevalence may reduce the noncardiovascular mortality risk of lighter drinkers.







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